MENUMENU
Some Highlights of BPC-157
BPC-157 is a peptide chain consisting of 15 amino acids. It is synthetic because this particular sequence does not exist in nature. BPC is derived from a protective protein found in the stomach. The majority of studies on BPC-157 have been done on rats given injections of the supplement.
BPC-157 (C62-H98-N16-O22).
Is a fifteen amino acid sequence of the following:
L-Valine,glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-; glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine.
BPC 157 has been shown in rat studies to heal torn quadriceps muscles, detached Achilles tendon, muscle tissue that has been damaged/crushed
No adverse reactions in human trials.
The main characteristics of healing are granulation tissue, angiogenesis, and production of collagen. BPC-157 facilitates angiogenesis. Angio (vessel) genesis (formation) is the formation of vessels. BPC-157 acts by modulating Vaso Endothelial Growth Factor (VEGF) which is the growth factor that causes capillaries to grow into a new area to carry blood and nutrients. Blood flow carrying nutrients is how healing happens. Blood flow only occurred in actual tendon and muscle tissue, in cell cultures BPC-157 did not affect VEGF or healing. Typically Blood supply to an ulcer and a tendon is deficient, so ulcers don’t heal and neither do tendons. However, with a drug which can increase healing in tendons athletes can break through new plateaus without the fear that their body may fall apart if they lift too heavy.
Research Backing BPC-157
The study used two groups of tendon explants of which one group was cultured in a BPC 157-containing medium while the other group was cultured in a medium lacking BPC 157. These cultures were thereafter examined for tendon fibroblasts outgrowths. Such outgrowths indicated tendon regeneration. The results revealed that the explants’ outgrowth was significantly accelerated in the culture containing BPC 157 as compared to the culture lacking BPC 157. Also, an MTT assay did show that BPC 157 does not directly affect cellular proliferation in a culture of the rat-derived Achilles tendon. However, results also showed that BPC 157 significantly increased the survival of cells under oxidative stress. Furthermore, the Transwell filter migration assay showed that BPC 157 significantly increased in-vitro fibroblast migration in a dose-dependent fashion. Moreover, BPC 157 accelerated the dispersal of the fibroblasts in culture dishes in a dose-dependent manner.
I have personally used BPC more than one time now and have seen many of my close friends and family use it as well. My first personal experience was on my knee. I had tweaked my knee doing heavy Hack squats without warming up enough first. I hurt it bad enough that I couldn’t make it through my workout. The next day I could barely walk up stairs and had lift one leg at a time. I waited three days, but nothing changed, and I started to fear I may be looking at surgery. My knee was swollen in the meniscus area but not bruised or anything severe. I decided it was time to give this BPC-157 a try after doing as much research as I could I bought 2 – 5mg vials of BPC-157.I added 1ml of Bacteriostatic water to the first vial very carefully knowing that this is a fragile peptide (BPC should be refrigerated after reconstitution). I started with a dose of 250mcg two times per day injected directly into the site of injury. I found that injecting in a triangle pattern around the injury seemed to work best for me. I would use three spots around the injury area within 1 in of the actual pain. Within a few hours of doing the first injection, I started to feel like the pain had lessened. I thought this was for sure a placebo effect. After the second injection, I didn’t notice much more than the first one, but overall it was feeling slightly better. Next day I work up, and I saw the swelling was gone and I could move my knee a good bit better than the day before I still just figured it was a coincidence. I used the same dose 250mcg twice that day. I woke up on the third day and got out of bed without really thinking about the knee. Before I had realized it I was downstairs making a protein shake then it hit me. I wasn’t able to go down the steps like that the day before. I was still going one step at a time. At this point, I realized this stuff was no joke, and there is something really to it. I continued the same dosing schedule for the next few days until I finished the 5mg bottle. So ten days in I was feeling about 90% better from the injury. I was feeling well enough to start back to training legs at about 80% of my average capacity. I started on the second bottle, but this time I did a single injection per day at 500mcg instead of the two 250mcg injections. I didn’t notice much of a difference. I kept training and slowly increased back to my standard training capacity. Twenty days in I finished the second bottle and decided to stop since I was almost back to 100%. I was very impressed by my experience and started to tell people I knew about it. Looking back I realized I should have not trained legs at all and tried to give it time to heal completely because it felt like I got almost to 100% but not quite.Overall, I was very impressed and blown away. A few months go by, and I hurt my shoulder.I decided to give the BPC another go around. I dosed it the same as last time 250mcg 2 times a day. This time my minor shoulder flare-up seemed to heal within the first ten days. The pain in my AC joint was going by the time I finished the first bottle. I was so impressed that I told a few people who also decided to give it a try. Most of them had similar results, but I noticed that not everyone got the same effects. There were one or two people who didn’t think it did much for them, but there wasn’t a negative either, so it was worth a shot. We were all buying from different research chem sites at the time for “research purposes” of course. I think this may have been why some got results and others did not as well. The quality was not very consistent and who knows if we were all getting real BPC-157 or if the BPC had not been damaged in the handling process of acquiring it. We did a youtube video on BPC and got our youtube privileges suspended because of it. Even though it was for entertainment purposes only and that was clearly stated. We did get the acct back but have not posted any videos that are even remotely in the gray area since.I will link the video to the Anaboliccartel.com site. If you want to check it out. I have used BPC once since these two experiences, but this time I was able to get it with a prescription from a doctor. There is one pharmacy in the US which is dispensing BPC with a prescription and let me say it worked even better than my first two experiences but also cost at least three times more than I paid for BPC from the research sites. If you want info on how to get an actual prescription for the real deal BPC email at info@tgbsupplements.com Working with Regenesis HRT Pittsburgh I have been able to help others get set up legally. There is nothing better than US Pharm grade medications.
My final thoughts on this compound are that it is very impressive and can be used as a tool if needed to help heal from certain types of injuries. It may not work for every person or every injury, but it would be one of the first tools I would utilize in an attempt to heal an injury. I think injecting close to the injury site is the best way to get the full benefits from the compound unless you need it to heal in the digestive tract in which case oral administration is best. I would use a 29g ½ in insulin syringe for the injections. Injecting with an insulin needle is nearly painless for most sites. For things like bursitis, tendonitis, strains, muscle tears, and sprains this medication shows excellent potential in my opinion. With little to no side effects know to date it is worth a shot in my opinion. Quality would be a significant concern for getting the benefits so if possible try to get it from an actual US pharmacy and to my knowledge there is only currently one that is compounding BPC. If you want more info on this contact me for info and I can get you set up with a Doctor who can get you a prescription if he feels it can benefit you. I am happy to have something that I can use if an injury does occur. There is nothing worse than getting set back by an injury.For some athletes, this compound could be a real game changer. I am not sure of the current legal status in sports governing bodies, but to my knowledge, it is still not banned by WADA which means it should be of interest to any advanced athlete pushing the limits of the body. The only drawback I see is that there are no long term human studies. That is always going to leave some uncertainty, but when you are a professional athlete, sometimes the risk is worth it. Combining BPC with something like IGF-1 or GH could be interesting when it comes to healing after an injury. Hopefully, we will see more studies come out over time or at the very least more people sharing their experiences. Until this, I will keep this ace up my sleeve!
References:
Written by,Trevor Benko