It’s an injectable medication that mimics the effects of glucagon-like peptide-1, GLP-1, which helps to improve insulin sensitivity and control blood sugar levels while reducing feelings of hunger, thus promoting weight loss while maintaining overall health.
GLP-1 agonists are members of one of the newest classes of medications used to treat Type-2 diabetes. When GLP-1 agonists were initially used to treat Type-2 diabetes many patients also lost weight and were found to have a host of health benefits including a reduction of cardiovascular events such as coronary artery disease and stroke, prevention and regression of Type-2 diabetes plus many others. GLP-1 agonists are maximally effective for weight loss at doses that are significantly higher than what is currently recommended for the treatment of Type-2 diabetes.
GLP-1 agonists are marketed under different brand names for the treatment of Type-2 Diabetes, and for the treatment of obesity and in patients that are overweight who also have other cardiometabolic risk factors such as hypertension, pre-diabetes, Type-2 diabetes, and hyperlipidemia, to name a few. Currently, some of these medications are generally not covered by insurance and cost about $1,300 per month. Despite this, at the time that this article was written, one of the most popular medications was listed on the FDA list of drugs that are in short supply.
GLP-1 agonists are safe and well-tolerated, with minimal side effects. When people do get side effects, they are generally mild and often improve over time. To minimize their occurrence the medication is started at a very low dose and increased gradually over 5 weeks. Studies show that maximal weight loss is achieved at the maximal dose. The most common side effects of from the medication are gastro-intestinal such as nausea, vomiting, abdominal pain, heartburn, bloating, diarrhea, constipation, upset stomach, belching, and gas. Fatigue, headache, tiredness, and dizziness are less common.
Some patients report that if GLP-1 agonist medication is stopped, weight loss is reversed. That being said, there are no studies to determine if behavioral support and lifestyle changes will prevent weight gain if GLP-1 agonist treatment is stopped. What is known is that obesity is epidemic and resistant to conventional treatments and is associated with significant morbidity and mortality.
GLP-1 agonists have been shown to be a game-changer in the fight against obesity and the fight against coronary artery disease, stroke, Type-2 Diabetes, premature death and disability. Therefore, using GLP-1 agonists for treating high risk chronically overweight patients is a very reasonable option and a lifesaver for many.
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Matt has gone above and beyond to help identify health issues and ensure proper treatment. Great guy!
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